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Item type:Publication, Access status: with files , Strategies and process development for particle formation from aquasolv lignin and innovative applications into consumer goods(2022); Aquasolv lignin is a high-molecular weight biopolymer obtained after the pre-treatment of lignocellulosic biomass with liquid hot water (LHW) under elevated pressure followed by enzymatic hydrolysis. Due to its free-of-solvent nature and vegetal primary source, lignin applicability opens to high value products as the case for cosmetic, food and pharmaceutical industries. However, current process yields a heterogeneous material and does not control characteristics such as particle size and morphology, such features being important due to their direct impact in biological behaviour and technical properties; for instance, bioavailability, flowability and solubility in pharmaceutical excipients. The selection of an appropriate method to obtain particles with controlled mean size appears crucial to further product development and formulation. In this regard; a whole process line from crude biomass to lignin powders for the food and pharmaceutical industries has been developed. In the present study, the focus was to tailor the final quality of the lignin in terms of particle size and water content by using spray drying technology. A three-factor central composite rotatory design was used, and the independent variables selected for the set of experiments were inlet temperature, nozzle pressure and feeding rate. The effect of these factors and their interaction was studied and used to model the particle formation and properties of lignin. A thorough evaluation of the bioactive properties and cytototoxicity of the obtained AS lignin particles was assessed in vitro, and for the first time, the non cytotoxicity and hypocholesterolemic effect of AS lignin was demonstrated in vivo in a rat model. The results of this thesis are the basis for further valorizing lignin from second generation biorefineries and apply the material into valuable product formulation by using the principles of particle engineering design.Publicationtype: Doctoral Thesis220 878