A 3D-printable Flow Cell for in-line NMR Spectroscopy & Relaxometry

The presented model is a resin 3D-printable flow cell for in-line measurements in a Spinsolve 80 Carbon Ultra (Magritek GmbH) bench top nuclear magnetic resonance spectrometer. It is designed to be fully printable without any post-printing modifications. The two column parts thread into each other and provide a cavity of 500 μL that is intended to hold immobilized enzyme for flow catalysis or empty resins for dynamic relaxometry experiments. The upper and lower column part each has an integrated mesh of 0.125 μm pore size to hold typical resins. The threaded fittings are designed to use regular 1/16" HPLC tubing. To create a proper seal inside the column, the tubing has to be flanged using, e.g., a thermoelectric flanging tool. The column is filled, assembled and can finally be placed in the opening of the NMR device.