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Contact behavior of microcrystalline cellulose pellets depending on their water content
Citation Link: https://doi.org/10.15480/882.2758
Publikationstyp
Journal Article
Date Issued
2020-03-12
Sprache
English
TORE-DOI
TORE-URI
Volume
43
Issue
5
Start Page
887
End Page
895
Citation
Chemical Engineering and Technology 5 (43): 887-895 (2020-05-01)
Publisher DOI
Scopus ID
Publisher
Wiley-VCH Verl.-Ges.
Microcrystalline cellulose pellets for oral drug delivery are often produced by a combined wet extrusion-spheronization process. During the entire process, the cylindrical as well as the spherical pellets are exposed to various stresses resulting in a change of their shape and size due to plastic deformation and breakage. In this work, the effect of moisture content of pellets on their mechanical behavior is studied. In static compression tests, the strong influence of water content on deformation behavior of pellets is confirmed. Moreover, impact tests are performed using a setup consisting of three high-speed cameras to record pellet-wall collisions. Material properties, such as stiffness, restitution coefficient, breakage force, and displacement, were analyzed depending on the water content.
Subjects
Compression test
Extrusion
Microcrystalline cellulose pellets
Spheronization
Water content
DDC Class
540: Chemie
600: Technik
More Funding Information
This study was conducted within two research projects funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Project-ID AN 782/12-1 and AN 782/2-1.
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