Options
Continuous Countercurrent Extractive Biocatalysis in Aqueous Surfactant Two-Phase Systems
Publikationstyp
Journal Article
Date Issued
2018-03
Sprache
English
Author(s)
Institut
TORE-URI
Journal
Volume
90
Issue
3
Start Page
348
End Page
357
Citation
Chemie-Ingenieur-Technik 3 (90): 348-357 (2018-03)
Publisher DOI
Scopus ID
To evaluate the possibility of performing extractive biocatalysis in continuous mode, the hydrolysis of penicillin G in a micellar solution containing the nonionic surfactant Tergitol NP-7 was chosen as model system. While the product phenylacetic acid distributes into the micellar phase, 6-aminopenicillanic acid moves preferably into the aqueous phase. The yield in the continuous multi-step process was higher in comparison to equivalent batch systems. Overall, the results demonstrate the suitability of aqueous surfactant two-phase systems for continuous biocatalytic reactive extraction processes.
More Funding Information
DFG Project SM 82/14-1