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Multiscale modeling of bone healing : toward a systems biology approach
Publikationstyp
Review Article
Date Issued
2017-05-08
Sprache
English
Author(s)
Journal
Volume
8
Issue
MAY
Article Number
287
Citation
Frontiers in Physiology 8 (5): 287 (2017)
Publisher DOI
Scopus ID
Publisher
Frontiers Media SA
Bone is a living part of the body that can, in most situations, heal itself after fracture. However, in some situations, healing may fail. Compromised conditions, such as large bone defects, aging, immuno-deficiency, or genetic disorders, might lead to delayed or non-unions. Treatment strategies for those conditions remain a clinical challenge, emphasizing the need to better understand the mechanisms behind endogenous bone regeneration. Bone healing is a complex process that involves the coordination of multiple events at different length and time scales. Computer models have been able to provide great insights into the interactions occurring within and across the different scales (organ, tissue, cellular, intracellular) using different modeling approaches [partial differential equations (PDEs), agent-based models, and finite element techniques]. In this review, we summarize the latest advances in computer models of bone healing with a focus on multiscale approaches and how they have contributed to understand the emergence of tissue formation patterns as a result of processes taking place at the lower length scales.
Subjects
Bone healing
Computer modeling
Multiscale modeling
Systems biology
Tissue regeneration
DDC Class
610: Medicine, Health