Options
Challenges in industrial fermentation technology research
Publikationstyp
Journal Article
Date Issued
2014-06
Sprache
English
Author(s)
Formenti, Luca Riccardo
Nørregaard, Anders
Bolic, Andrijana
Hernandez, Daniela Quintanilla
Hagemann, Timo
Larsson, Hilde
Mears, Lisa
Krühne, Ulrich
Journal
Volume
9
Issue
6
Start Page
727
End Page
738
Citation
Biotechnology Journal 9 (6): 727-738 (2014-06)
Publisher DOI
Scopus ID
Publisher
Wiley-VCH Verlag
Industrial fermentation processes are increasingly popular, and are considered an important technological asset for reducing our dependence on chemicals and products produced from fossil fuels. However, despite their increasing popularity, fermentation processes have not yet reached the same maturity as traditional chemical processes, particularly when it comes to using engineering tools such as mathematical models and optimization techniques. This perspective starts with a brief overview of these engineering tools. However, the main focus is on a description of some of the most important engineering challenges: scaling up and scaling down fermentation processes, the influence of morphology on broth rheology and mass transfer, and establishing novel sensors to measure and control insightful process parameters. The greatest emphasis is on the challenges posed by filamentous fungi, because of their wide applications as cell factories and therefore their relevance in a White Biotechnology context. Computational fluid dynamics (CFD) is introduced as a promising tool that can be used to support the scaling up and scaling down of bioreactors, and for studying mixing and the potential occurrence of gradients in a tank. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
Computational fluid dynamics
Fermentation process development
Fungal morphology
Industrial biotechnology
Modeling
Scale-down bioreactors
DDC Class
570: Life Sciences, Biology