Enzymatic carboxylation of resorcinol in aqueous triethanolamine: first steps towards a lab-scale production process

Publikationstyp
Doctoral Thesis
Date Issued
2022
Sprache
English
Author(s)
Ohde, Daniel  orcid-logo
Advisor
Liese, Andreas  orcid-logo
Referee
Schlüter, Michael  orcid-logo
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2021-12-10
Institut
Technische Biokatalyse V-6  
TORE-DOI
10.15480/882.4115
TORE-URI
http://hdl.handle.net/11420/11543
Citation
Technische Universität Hamburg (2022)
The triethanolamine-mediated enzymatic carboxylation of resorcinol was investigated, where CO2 is used as resource. The reaction system was characterized and different strategies to improve reaction yields tested. In this work, a process was established and characterized to produce 2,6-dihydroxybenzoic acid in a purity of over 99.8%. This was enabled by the application of a suitable adsorbent for in situ product removal. Furthermore, the CO2 gassing was optimized with microbubble gassing, which improved the mass transfer, CO2 utilization and reduced foam formation. The gained insights into the amine-based enzymatic carboxylation helps to promote this process for industrial application.
Subjects
CO2
Carboxylation
Decarboxylation
Biotransformation
Microbubble
CO2 capture
DDC Class
660: Technische Chemie
Lizenz
https://creativecommons.org/licenses/by/4.0/
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