Advanced Process and Control Strategies for Bioreactors

Start Page
463
End Page
493
Citation
Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls: 463-493 (2017)
Publisher DOI
10.1016/B978-0-444-63663-8.00016-1
Scopus ID
2-s2.0-85010886901
Publisher
Elsevier
ISBN
978-0-444-63663-8
978-0-444-63674-4
Bioreactor processes have to provide an almost optimal environment to microorganisms or cells to promote growth and product formation. The design and operation of a bioreactor as the main element of fermentation is a complex task, not only with respect to a reactor's configuration and size but to the control and mode of operation. In this chapter, some fundamentals are discussed, including process and control strategies and concepts for process development. Next, examples for the use of model-based concepts for the design of experiments, feeding strategies, seed train layout, and control strategies, including simulation tools supporting biotechnological training and education, are shown.
Subjects
Bioreactor
Design of experiments
Fed-batch
Model-based control
Process analytical technologies
Process simulation
Process strategy
Quality by design
DDC Class
620: Ingenieurwissenschaften