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Development of a system for fast identification and characterization of biological cells
Citation Link: https://doi.org/10.15480/882.8691
Publikationstyp
Doctoral Thesis
Date Issued
2023
Sprache
English
Author(s)
Advisor
Referee
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2023-06-07
Institute
TORE-DOI
Citation
Technische Universität Hamburg (2023)
Bio Impedance Spectroscopy (BIS) is the application of a signal with varying frequency to a biological material and measuring its frequency response. This research explores BIS to distinguish cancer and healthy cells and tissues, and also metastatic from non-metastatic cancers. The first important finding is one physical characteristic that distinguishes metastatic from non-metastatic cancer cells: the cell surface charge. For all researched cancer groups the cell surface charge per area was found to be smaller for more metastatic cancers than for less metastatic ones. Another finding was that cancer tissues in general have a lower impedance magnitude than healthy ones. An important conclusion is that healthy and cancer tissues and cells show a different spectral behavior, which is close correlated to the effects of the cancer in the healthy cells and tissues.
Subjects
Cancer
Electrical Impedance Spectroscopy
Bio Impedance Spectroscopy
metastatic cancer
spectral response
cell surface charge
cell chare
DDC Class
610: Medicine, Health
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Teixeira_Silva_Viviane_Development_System_Fast_Identification_Characterization_Biological_Cells.pdf
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