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  4. Global yield isotherms and kinetic of artemisinin extraction from Artemisia annua L leaves using supercritical carbon dioxide
 
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Global yield isotherms and kinetic of artemisinin extraction from Artemisia annua L leaves using supercritical carbon dioxide

Publikationstyp
Journal Article
Date Issued
2005-04-26
Sprache
English
Author(s)
Quispe-Condori, Sócrates  
Sánchez, Deny  
Foglio, Mary Ann  
de Tarso Vieira e Rosa, Paulo  
Zetzl, Carsten  
Brunner, Gerd  
Meireles, Maria Angela A.  
Institut
Thermische Verfahrenstechnik V-8  
TORE-URI
http://hdl.handle.net/11420/14077
Journal
The journal of supercritical fluids  
Volume
36
Issue
1
Start Page
40
End Page
48
Citation
Journal of Supercritical Fluids 36 (1): 40-48 (2005-11-01)
Publisher DOI
10.1016/j.supflu.2005.03.003
Scopus ID
2-s2.0-24944452797
Publisher
Elsevier
Artemisinin is an effective drug used in the malaria treatment. This drug, present in the Artemisia annua L leaves, was extracted using pressurized CO 2 as solvent. The artemisinin global yields isotherms were determined at 30 and 50 °C with pressures in the range of 75-400 bars. The influences of temperature, pressure, and solvent flow rate on the extraction kinetics were also investigated, using a complete factorial design 23 (pressures of 200 and 400 bars, temperature of 30 and 50 °C and CO2 mass flow rate of 5.5 × 10-5 and 11.1 × 10-5 kg CO 2/s). Extracts of A. annua L. leaves were also prepared by hydrodistillation and hexane Soxhlet. The mass transfer coefficients for constant extraction rate period were obtained from the experimental data. The extracts were analyzed by GC-FID and the artemisinin content was determined by the indirect method. The maximum artemisinin global yields were obtained at 30 °C and 150 bar (0.62% dry basis - d.b.) and 50 °C and 300 bar (0.70% d.b.). The extract obtained by hydrodistillation presented no artemisinin and the main compounds presented were camphor, β-caryophyllene, borneol e 1,8-cineol. The hexane Soxhlet artemisinin yield was 0.77% in dry basis. The experimental extraction curves were well fitted by the mathematical models of Sovová and Martinez et al., and by the empirical model.
Subjects
Artemisia annua
Artemisinin
Global yield
Kinetic
Mathematical modeling
Supercritical fluid extraction
DDC Class
540: Chemie
600: Technik
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