Modeling suspension cultures of microbial and mammalian cells with an adaptable six-compartment model

Journal
Chemical engineering & technology  
Volume
40
Issue
5
Start Page
956
End Page
966
Citation
Chemical Engineering and Technology 5 (40): 956-966 (2017-05-01)
Publisher DOI
10.1002/ceat.201600639
Scopus ID
2-s2.0-85017401820
Publisher
Wiley-VCH Verl.-Ges.
Process models can be used for model-based control strategies, but model development is a time-consuming and laborious task. To reduce the modeling effort, a new structured compartment model was developed, which may easily be adapted to different cultivation processes. The proposed six-compartment model was used to describe the time courses of cultivations of bacteria, yeast, fungi, and mammalian cell lines, namely, Escherichia coli, Lactobacillus delbrueckii, Saccharomyces cerevisiae, Cyathus striatus, and a hybridoma mammalian cell line. The model can describe the time courses of important state variables and can be adapted to the cultivation processes by parameterization. This reduces the modeling effort for a new process significantly.
Subjects
Compartment models
Fungi
Mammalian cells
Microorganisms
Suspension cultivation
DDC Class
600: Technik
620: Ingenieurwissenschaften
More Funding Information
Financial support of the Bundesministerium für Bildung und Forschung (FKZ: 031A124 A-C) and City University of Applied Sciences Bremen enabling us to perform this research.