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Predicting solvation free energies for neutral molecules in any solvent with openCOSMO-RS
Citation Link: https://doi.org/10.15480/882.13678
Publikationstyp
Journal Article
Date Issued
2024-10-16
Sprache
English
Author(s)
TORE-DOI
Journal
Volume
589
Article Number
114250
Citation
Fluid Phase Equilibria 589: 114250 (2025)
Publisher DOI
Scopus ID
Publisher
Elsevier
In this study, we introduce openCOSMO-RS 24a, an improved version of the open-source COSMO-RS model parameterized using quantum chemical calculations from ORCA 6.0, leveraging a comprehensive dataset that includes solvation free energies, partition coefficients, and infinite dilution activity coefficients for various solutes and solvents mainly at 25 °C. This is the first version of the model also capable of predicting solvation free energies based on ORCA calculations. Additionally, we develop a Quantitative Structure-Property Relationships model to predict molar volumes of the solvents, an essential requirement for predicting solvation free energies and partition coefficients from structure alone. Our results show that openCOSMO-RS 24a achieves an average absolute deviation of 0.45 kcal mol1 for solvation free energies, 0.76 for the logarithm of the partition coefficients, and 0.51 for the logarithm of infinite dilution activity coefficients, demonstrating improvements over the previous openCOSMO-RS 22 parameterization and comparable results to COSMOtherm 24 BP-TZVP. The user interface was extended to be able to use it as solvation model directly from within ORCA 6.0 or from the command line to provide researchers with a robust tool for applications in chemical and materials science.
Subjects
Activity coefficients
COSMO-RS
openCOSMO-RS
Partition coefficients
Phase equilibrium
Solvation free energies
DDC Class
541: Physical; Theoretical
530: Physics
004: Computer Sciences
660: Chemistry; Chemical Engineering
Publication version
publishedVersion
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1-s2.0-S0378381224002255-main.pdf
Type
Main Article
Size
1.51 MB
Format
Adobe PDF