Genome sequence of type strain Paenibacillus polymyxa DSM 365, a highly efficient producer of optically active (R,R)-2,3-butanediol

Journal
Journal of biotechnology  
Volume
195
Start Page
72
End Page
73
Citation
Journal of Biotechnology 195: 72-73 (2015-02-01)
Publisher DOI
10.1016/j.jbiotec.2014.07.441
Scopus ID
2-s2.0-84920664109
PubMed ID
25450636
Publisher
Elsevier Science
Paenibacillus polymyxa DSM 365, an efficient producer of (R,. R)-2,3-butanediol, is known to show the highest production titer and productivity reported to date. Here, the first draft genome sequence of this promising strain may provide the genetic basis for further insights into the molecular mechanisms underlying the production of (R,. R)-2,3-butanediol with high optical purity and at a high titer. It will also facilitate the design of rational strategies for further strain improvements, as well as construction of artificial biosynthetic pathways through synthetic biology for asymmetric synthesis of chiral 2,3-butanediol or acetoin in common microbial hosts.
Subjects
(R,R)-2,3-butanediol
Genome sequence
High optical purity
Paenibacillus polymyxa
DDC Class
540: Chemie
570: Biowissenschaften, Biologie
More Funding Information
The work was supported by CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Chinese Academy of Sciences (KLIM-201304), the Guangxi Science and Technology Development Project (14125008-2-22 and 12118004-4), the Guangxi Natural Science Foundation (2012GXNSFBA053063), and the National Natural Science Foundation of China (31360207).