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  4. Rapid Detection of SARS-CoV-2 Antigens and Antibodies Using OFET Biosensors Based on a Soft and Stretchable Semiconducting Polymer
 
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Rapid Detection of SARS-CoV-2 Antigens and Antibodies Using OFET Biosensors Based on a Soft and Stretchable Semiconducting Polymer

Publikationstyp
Journal Article
Date Issued
2023-05-08
Sprache
English
Author(s)
Ditte, Kristina  
Nguyen Le, Trang Anh  
Ditzer, Oliver  
Sandoval Bojorquez, Diana Isabel  
Chae, Soosang  
Bachmann, Michael  
Baraban, Larysa  
Lissel, Franziska  
Angewandte Polymerphysik M-EXK 6  
TORE-URI
http://hdl.handle.net/11420/15099
Journal
ACS biomaterials science & engineering  
Volume
9
Issue
5
Start Page
2140
End Page
2147
Citation
ACS Biomaterials Science and Engineering 9 (5): 2140-2147 (2023-05-08)
Publisher DOI
10.1021/acsbiomaterials.1c00727
Scopus ID
2-s2.0-85116056304
In the midst of the COVID-19 pandemic, adaptive solutions are needed to allow us to make fast decisions and take effective sanitation measures, e.g., the fast screening of large groups (employees, passengers, pupils, etc.). Although being reliable, most of the existing SARS-CoV-2 detection methods cannot be integrated into garments to be used on demand. Here, we report an organic field-effect transistor (OFET)-based biosensing device detecting of both SARS-CoV-2 antigens and anti-SARS-CoV-2 antibodies in less than 20 min. The biosensor was produced by functionalizing an intrinsically stretchable and semiconducting triblock copolymer (TBC) film either with the anti-S1 protein antibodies (S1 Abs) or receptor-binding domain (RBD) of the S1 protein, targeting CoV-2-specific RBDs and anti-S1 Abs, respectively. The obtained sensing platform is easy to realize due to the straightforward fabrication of the TBC film and the utilization of the reliable physical adsorption technique for the molecular immobilization. The device demonstrates a high sensitivity of about 19%/dec and a limit of detection (LOD) of 0.36 fg/mL for anti-SARS-Cov-2 antibodies and, at the same time, a sensitivity of 32%/dec and a LOD of 76.61 pg/mL for the virus antigen detection. The TBC used as active layer is soft, has a low modulus of 24 MPa, and can be stretched up to 90% with no crack formation of the film. The TBC is compatible with roll-to-roll printing, potentially enabling the fabrication of low-cost wearable or on-skin diagnostic platforms aiming at point-of-care concepts.
Subjects
anti-SARS-CoV-2 antibodies sensor
biosensors
block copolymers
organic field-effect transistors
SARS-CoV-2 antigen sensor
semiconducting polymers
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