Technical strategies to improve tissue engineering of cartilage-carrier- constructs

Journal
Advances in biochemical engineering, biotechnology  
Volume
112
Start Page
145
End Page
181
Citation
Advances in Biochemical Engineering/Biotechnology 112: 145–181 (2009)
Publisher DOI
10.1007/978-3-540-69357-4_7
Scopus ID
2-s2.0-62849083646
Publisher
Springer
ISBN
9783540693567
Technical aspects play an important role in tissue engineering. Especially an improved design of bioreactors is crucial for cultivation of artificial three-dimensional tissues in vitro. Here formation of cartilage-carrier- constructs is used to demonstrate that the quality of the tissue can be significantly improved by using optimized culture conditions (oxygen concentration, growth factor combination) as well as special bioreactor techniques to induce fluid-dynamic, hydrostatic or mechanical load during generation of cartilage. © 2009 Springer.
Subjects
Cartilage
Chondrocytes
Growth factors
Mechanical load
Osteochondral implants
Re-differentiation
DDC Class
610: Medicine, Health
620: Engineering