Modellierung der mittleren Phaseder HIV-Infektion unter Medikation

Other Titles
Modelling the middle phase of HIV infection during medication
Publikationstyp
Journal Article
Date Issued
2003
Sprache
German
Author(s)
Lichtenberg, Gerwald  
Nolde, Kristian  
Riedel, Uta  
Schwank, Alexander  
Stellbrink, Hans Jürgen  
Institut
Regelungstechnik E-14  
TORE-URI
http://hdl.handle.net/11420/14932
Journal
AT Automatisierungstechnik  
Volume
51
Issue
10
Start Page
462
End Page
470
Citation
At-Automatisierungstechnik 51 (10): 462-470 (2003)
Publisher DOI
10.1524/auto.51.10.462.19575
Scopus ID
2-s2.0-85041087021
Publisher
De Gruyter
This paper presents an approach to modelling the middle phase of the HIV infection with medication. The model describes the viral load, concentrations of healthy and infected CD4+- T-cells and CD8+-T-cells in blood. Processes of death, birth, and infection are regarded, as well as infection inhibition and control processes for cell concentrations of the immune system. The main difference between HIV and other infections can then be interpreted in terms of the internal coupling structure. The parameters of the model are estimated with the help of clinical data. A method to predict the effect of medication, based on a measurement of initial cell concentrations before therapy begins, is presented. © Oldenbourg Verlag.
Subjects
Antiretroviral therapy
HIV infection
Immune system
Nonlinear modelling
DDC Class
600: Technik
610: Medizin
620: Ingenieurwissenschaften