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  4. Skeletal maturity leads to a reduction in the strain magnitudes induced within the bone : a murine tibia study
 
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Skeletal maturity leads to a reduction in the strain magnitudes induced within the bone : a murine tibia study

Publikationstyp
Journal Article
Date Issued
2015-02-01
Sprache
English
Author(s)
Razi, Hajar
Birkhold, Annette I.
Zaslansky, Paul
Weinkamer, Richard  
Duda, Georg  
Willie, Bettina M.  
Checa Esteban, Sara  
TORE-URI
https://hdl.handle.net/11420/48228
Journal
Acta biomaterialia  
Volume
13
Start Page
301
End Page
310
Citation
Acta Biomaterialia 13: 301-310 (2015)
Publisher DOI
10.1016/j.actbio.2014.11.021
Scopus ID
2-s2.0-84920738604
Publisher
Elsevier
Bone adapts to changes in the local mechanical environment (e.g. strains) through formation and resorption processes. However, the bone adaptation response is significantly reduced with increasing age. The mechanical strains induced within the bone by external loading are determined by bone morphology and tissue material properties. Although it is known that changes in bone mass, architecture and bone tissue quality occur with age, to what extent they contribute to the altered bone adaptation response remains to be determined. This study investigated alterations in strains induced in the tibia of different aged female C57Bl/6J mice (young, 10-week-old; adult, 26-week-old; and elderly, 78-week-old) subjected to in vivo compressive loading. Using a combined in vivo/in silico approach, the strains in the bones were assessed by both strain gauging and finite element modeling experiments. In cortical bone, strain magnitudes induced at the mid-diaphysis decreased by 20% from young to adult mice and by 15% from adult to elderly mice. In the cancellous bone (at the proximal metaphysis), induced strains were 70% higher in young compared with adult and elderly mice. Taking into account previous studies showing a reduced bone adaptation response to mechanical loading in adulthood, these results suggest that the diminished adaptive response is in part due to a reduction in the strains induced within the bone.
Subjects
Age
Finite element modeling
Mechanical strains
Mouse tibial compression
DDC Class
610: Medicine, Health
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