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A 3D in silico multi-tissue evolution model highlights the relevance of local strain accumulation in bone fracture remodeling
Publikationstyp
Journal Article
Date Issued
2022-03-31
Sprache
English
Author(s)
Volume
10
Article Number
835094
Citation
Frontiers in Bioengineering and Biotechnology 10: 835094 (2022)
Publisher DOI
Scopus ID
Publisher
Frontiers Media SA
Since 5–10% of all bone fractures result in non-healing situations, a thorough understanding of the various bone fracture healing phases is necessary to propose adequate therapeutic strategies. In silico models have greatly contributed to the understanding of the influence of mechanics on tissue formation and resorption during the soft and hard callus phases. However, the late-stage remodeling phase has not been investigated from a mechanobiological viewpoint so far. Here, we propose an in silico multi-tissue evolution model based on mechanical strain accumulation to investigate the mechanobiological regulation of bone remodeling during the late phase of healing. Computer model predictions are compared to histological data of two different pre-clinical studies of bone healing. The model predicted the bone marrow cavity re-opening and the resorption of the external callus. Our results suggest that the local strain accumulation can explain the fracture remodeling process and that this mechanobiological response is conserved among different mammal species. Our study paves the way for further understanding of non-healing situations that could help adapting therapeutic strategies to foster bone healing.
Subjects
bone fracture remodeling
in silico modeling
in vivo validation
mechanobiology
multi-tissue evolution
DDC Class
610: Medicine, Health