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Hydrophilic silica aerogels as dermal drug delivery systems - Dithranol as a model drug
Publikationstyp
Journal Article
Date Issued
2008-02-14
Sprache
English
Volume
69
Issue
3
Start Page
935
End Page
942
Citation
European Journal of Pharmaceutics and Biopharmaceutics 69 (3): 935-942 (2008-08-01)
Publisher DOI
Scopus ID
PubMed ID
18423994
Publisher
Elsevier
A special class of porous silica materials, silica aerogels, was recently shown to be a potential candidate for oral drug delivery systems. It was demonstrated, that stability of drugs and their dissolution rate can essentially be improved through the adsorption on to these materials. In this work, drug loaded silica aerogels are firstly applied as dermal drug delivery systems. Dithranol is used as a representative drug since there is a need to enhance its dermal availability. The unstable and nearly water-insoluble drug exhibits a poor penetration. Release of dithranol from aerogels into various semi-solid formulations and its dissolution as well as the release and penetration into artificial membranes were investigated by Fourier-transform infrared attenuated total reflection (FTIR-ATR) spectroscopy. Two model membranes (one hydrophilic and one lipophilic) were applied. Several formulations were tested and the most promising one was used in order to study the penetration of dithranol into human stratum corneum (SC). Dithranol adsorbed on hydrophilic silica aerogels exhibited superior penetration behaviour compared to that of the standard ointment (dithranol in white soft paraffin).
Subjects
Dithranol
FTIR-ATR spectroscopy
Human stratum corneum
Hydrophilic silica aerogels
Model membranes
Penetration
Release
DDC Class
540: Chemie
More Funding Information
One of the authors (I.S.) appreciates the financial support of DFG (Project SM/82-1 and SM/82-3).