Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling

Constrained mixture models have successfully simulated many cases of growth and remodeling in soft biological tissues. So far, extensions of these models have been proposed to include either intracellular signaling or chemo-mechanical coupling on the organ-scale. However, no version of constrained mixture models currently exists that includes both aspects. Here, we propose such a version that resolves cellular signal processing by a set of logic-gated ordinary differential equations and captures chemo-mechanical interactions between cells by coupling a reaction-diffusion equation with the equations of nonlinear continuum mechanics. To demonstrate the potential of the model, we present 2 case studies within vascular solid mechanics: (i) the influence of angiotensin II on aortic growth and remodeling and (ii) the effect of communication between endothelial and intramural arterial cells via nitric oxide and endothelin-1.

Subjects

Cell signaling | Constrained mixture | Growth and remodeling | Homeostasis | Soft tissue

DDC Class

660.6: Biotechnology

Funding(s)

Projekt DEAL

Publication version

publishedVersion

Lizenz

https://creativecommons.org/licenses/by/4.0/

Name

s10237-024-01884-w.pdf

Type

Main Article

Size

2.73 MB

Format

Adobe PDF

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Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling