Einfluss von Hochdruck auf die Synthese von N-Acetylneuraminsäure in einem Festbettreaktor

Reich, Jannis Alexander

doi:https://doi.org/10.15480/882.15250

Einfluss von Hochdruck auf die Synthese von N-Acetylneuraminsäure in einem Festbettreaktor

Citation Link: https://doi.org/10.15480/882.15250

Publikationstyp

Doctoral Thesis

Date Issued

2025

Sprache

German

Author(s)

Reich, Jannis Alexander

Advisor

Liese, Andreas

Referee

Schlüter, Michael

Title Granting Institution

Technische Universität Hamburg

Place of Title Granting Institution

Hamburg

Examination Date

2025-06-03

Institute

Technische Biokatalyse V-6

TORE-DOI

10.15480/882.15250

TORE-URI

https://hdl.handle.net/11420/55827

Citation

Technische Universität Hambur: (2025)

The continuous application of high pressure in biotechnology was shown for the production of Neu5Ac starting from GlcNac and Pyr. Two immobilized enzymes were used. For the investigation of the reaction kinetic a fixed bed reactor and for the position of equilibrium a circular reactor was used. By using up to 1,300 bar the equilibrium was positively influenced by pressure. Pressure caused an increase in affinity for some reactants towards the enzymes. The high-pressure circular reactor in particular showed great potential due to two different pressure regimes (high pressure and ambient pressure) enabling an easy taking of samples while the reaction is at high pressure.