Co-cultures with integrated in situ product removal for lactate-based propionic acid production

Publikationstyp
Journal Article
Publikationsdatum
2020-02-13
Sprache
English
Author
Selder, Ludwig 
Sabra, Wael 
Jürgensen, Nikolai 
Lakshmanan, Alagappan 
Zeng, An-Ping orcid-logo
Institut
Bioprozess- und Biosystemtechnik V-1 
DOI
10.15480/882.2763
TORE-URI
http://hdl.handle.net/11420/6092
Enthalten in
Bioprocess and biosystems engineering 
Volume
43
Issue
6
Start Page
1027
End Page
1035
Citation
Bioprocess and Biosystems Engineering 6 (43): 1027-1035 (2020-06-01)
Publisher DOI
10.1007/s00449-020-02300-0
Scopus ID
2-s2.0-85079698536
Publisher
Springer
Propionic acid (PA) is a valuable organic acid for the food and feed industry, but no bioproduction at industrial scale exists so far. As product inhibition is a major burden for bioprocesses producing organic acids, in situ product removal (ISPR) is desirable. Here, we demonstrate a new strategy to produce PA with a co-culture coupled with ISPR using electrodialysis. Specifically, Bacillus coagulans first produces lactic acid (LA) from sugar(s) and LA is converted to PA using Veillonella criceti. Applying ISPR to the mentioned co-culture, the specific PA yield was increased from 0.35 to 0.39 g g−1 compared to no ISPR usage. Furthermore, the productivity was increased from 0.63 to 0.7 g L−1 h−1 by applying ISPR. Additionally, it was shown that co-consumption of xylose and glucose led to a higher PA productivity of 0.73 g L−1 h−1, although PA yield was only increased slightly up to 0.36 g g−1.
Schlagworte
Co-culture
Electrodialysis
In situ product removal
Propionic acid
DDC Class
600: Technik
Projekt(e)
TI-Bioraffinerien: ELBE-NH-Effektivitätssteigerung von Lignin Bioraffinerien durch ergänzende Nutzung von Hydrolysaten (Teilprojekt E) 
Projekt DEAL 
More Funding Information
Support by ERA-IB-2 (7th call) project BIOCHEM (Novel BIOrefinery platform methodology for a driven production of CHEMicals from low-grade biomass, ERA-IB-16-052), funded by the German Ministry of Education and Research (031B0270) and the project ELBE-NH: Effektivitätssteigerung von Lignin Bioraffinerien durch ergänzende Nutzung von Hydrolysaten, funded by the German Ministry of Education and Research (031B0660E).
Lizenz
https://creativecommons.org/licenses/by/4.0/
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