Options
Co-cultures with integrated in situ product removal for lactate-based propionic acid production
Citation Link: https://doi.org/10.15480/882.2763
Publikationstyp
Journal Article
Date Issued
2020-02-13
Sprache
English
Author(s)
Institut
TORE-DOI
TORE-URI
Volume
43
Issue
6
Start Page
1027
End Page
1035
Citation
Bioprocess and Biosystems Engineering 6 (43): 1027-1035 (2020-06-01)
Publisher DOI
Scopus ID
Publisher
Springer
Propionic acid (PA) is a valuable organic acid for the food and feed industry, but no bioproduction at industrial scale exists so far. As product inhibition is a major burden for bioprocesses producing organic acids, in situ product removal (ISPR) is desirable. Here, we demonstrate a new strategy to produce PA with a co-culture coupled with ISPR using electrodialysis. Specifically, Bacillus coagulans first produces lactic acid (LA) from sugar(s) and LA is converted to PA using Veillonella criceti. Applying ISPR to the mentioned co-culture, the specific PA yield was increased from 0.35 to 0.39 g g−1 compared to no ISPR usage. Furthermore, the productivity was increased from 0.63 to 0.7 g L−1 h−1 by applying ISPR. Additionally, it was shown that co-consumption of xylose and glucose led to a higher PA productivity of 0.73 g L−1 h−1, although PA yield was only increased slightly up to 0.36 g g−1.
Subjects
Co-culture
Electrodialysis
In situ product removal
Propionic acid
DDC Class
600: Technik
More Funding Information
Support by ERA-IB-2 (7th call) project BIOCHEM (Novel BIOrefinery platform methodology for a driven production of CHEMicals from low-grade biomass, ERA-IB-16-052), funded by the German Ministry of Education and Research (031B0270) and the project ELBE-NH: Effektivitätssteigerung von Lignin Bioraffinerien durch ergänzende Nutzung von Hydrolysaten, funded by the German Ministry of Education and Research (031B0660E).
Loading...
Name
Selder2020_Article_Co-culturesWithIntegratedInSit.pdf
Size
1.57 MB
Format
Adobe PDF