Variable gain amplifier for MPS

The magnetic response of superparamagnetic iron oxide nanoparticles (SPIONs) varies significantly during nucle-ation and growth, requiring adaptive signal conditioning to avoid saturation and maintain sensitivity. This work presents the design and experimental characterization of a low-noise variable gain amplifier (VGA) based on the AD603 for this application. The VGA offers a pin-selectable gain range from −10 dB to +30 dB, enabling high gain at early synthesis stages and controlled attenuation at later stages. Performance was evaluated in terms of transient response, gain, phase behavior, and noise characteristics over a frequency range of 1 kHz to 1 MHz. Measurements demonstrate stable gain, limited phase variation, and improved noise performance through parallel amplifier configurations, indicating suitability for low-noise, high-dynamic-range SPIONs measurement systems such as MPS/MPI devices.

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610: Medicine, Health

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Research funding: EU (EFRE) and the State Schleswig-Holstein (Projects: IMTE 1+2 – Grant: LPW-E1.1.1/1536, 124 20 002 and LPW21-L/2.2/262, 125 24 009).

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https://creativecommons.org/licenses/by/4.0/

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Variable gain amplifier for MPS