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  4. Motion-compensated OCT imaging of laryngeal tissue
 
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Motion-compensated OCT imaging of laryngeal tissue

Publikationstyp
Conference Paper
Date Issued
2024-02
Sprache
English
Author(s)
Latus, Sarah  orcid-logo
Medizintechnische und Intelligente Systeme E-1  
Kulas, Marica
Sprenger, Johanna  
Medizintechnische und Intelligente Systeme E-1  
Bhattacharya, Debayan  
Medizintechnische und Intelligente Systeme E-1  
Breda, Philippe C.
Wittig, Lukas  
Eixmann, Tim  
Hüttmann, Gereon  
Maack, Lennart  
Medizintechnische und Intelligente Systeme E-1  
Eggert, Dennis  
Betz, Christian Stephan  
Schlaefer, Alexander  
Medizintechnische und Intelligente Systeme E-1  
TORE-URI
https://hdl.handle.net/11420/47683
First published in
Progress in Biomedical Optics and Imaging - Proceedings of SPIE  
Number in series
12928
Article Number
1292809
Citation
SPIE Medical Imaging 2024
Contribution to Conference
SPIE Medical Imaging 2024  
Publisher DOI
10.1117/12.3006729
Scopus ID
2-s2.0-85192231823
Publisher
SPIE
ISBN
978-1-5106-7160-7
978-1-5106-7161-4
The increasing incidence of laryngeal carcinomas requires approaches for early diagnosis and treatment. In clinical practice, white light endoscopy of the laryngeal region is typically followed by biopsy under general anesthesia. Thus, image based diagnosis using optical coherence tomography (OCT) has been proposed to study sub-surface tissue layers at high resolution. However, accessing the region of interest requires robust miniature OCT probes that can be forwarded through the working channel of a laryngoscope. Typically, such probes generate A-scans, i.e., single column depth images, which are rather difficult to interpret. We propose a novel approach using the endoscopic camera images to spatially align these A-scans. Given the natural tissue motion and movements of the laryngoscope, the resulting OCT images show a three-dimensional representation of the sub-surface structures, which is simpler to interpret. We present the overall imaging setup and the motion tracking method. Moreover, we describe an experimental setup to assess the precision of the spatial alignment. We study different tracking templates and report root-mean-squared errors of 0.08mm and 0.18mm for sinusoidal and freehand motion, respectively. Furthermore, we also demonstrate the in-vivo application of the approach, illustrating the benefit of spatially meaningful alignment of the A-scans to study laryngeal tissue.
Subjects
Image based tracking
Laryngeal carcinoma
Motion compensation
Optical coherence tomography
DDC Class
005: Computer Programming, Programs, Data and Security
610: Medicine, Health
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