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Applications of coarse-grained models in metabolic engineering
Citation Link: https://doi.org/10.15480/882.8136
Publikationstyp
Journal Article
Date Issued
2022-03-08
Sprache
English
TORE-DOI
Journal
Frontiers in Molecular Biosciences
Volume
9
Start Page
1
End Page
14
Article Number
806213
Citation
Frontiers in Molecular Biosciences 9: 1-14 (2022-03-08)
Publisher DOI
Scopus ID
Mathematical modeling is a promising tool for better understanding of cellular processes. In recent years, the development of coarse-grained models has gained attraction since these simple models are able to capture and describe a broad range of growth conditions. Coarse-grained models often comprise only two cellular components, a low molecular component as representative for central metabolism and energy generation and a macromolecular component, representing the entire proteome. A framework is presented that presents a strict mass conservative model for bacterial growth during a biotechnological production process. After providing interesting properties for the steady-state solution, applications are presented 1) for a production process of an amino acid and 2) production of a metabolite from central metabolism.
Subjects
kinetic model
mathematical modeling
metabolic and gene regulatory networks
metabolic engineering
microbial growth
resource allocation
systems biotechnology
DDC Class
624: Civil Engineering, Environmental Engineering
Publication version
publishedVersion
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