Applications of coarse-grained models in metabolic engineering

Mathematical modeling is a promising tool for better understanding of cellular processes. In recent years, the development of coarse-grained models has gained attraction since these simple models are able to capture and describe a broad range of growth conditions. Coarse-grained models often comprise only two cellular components, a low molecular component as representative for central metabolism and energy generation and a macromolecular component, representing the entire proteome. A framework is presented that presents a strict mass conservative model for bacterial growth during a biotechnological production process. After providing interesting properties for the steady-state solution, applications are presented 1) for a production process of an amino acid and 2) production of a metabolite from central metabolism.

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Subjects

kinetic model

mathematical modeling

metabolic and gene regulatory networks

metabolic engineering

microbial growth

resource allocation

systems biotechnology

DDC Class

624: Civil Engineering, Environmental Engineering

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https://creativecommons.org/licenses/by/4.0/

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publishedVersion

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fmolb-09-806213.pdf

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2.01 MB

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