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Applications of coarse-grained models in metabolic engineering
Citation Link: https://doi.org/10.15480/882.8136
Publikationstyp
Journal Article
Publikationsdatum
2022-03-08
Sprache
English
Author
Doan, Dieu Thi
Systems Biotechnology, TUM School of Engineering and Design, Technische Universität München, Garching, Germany
Hoang, Manh Dat
Biochemical Engineering, TUM School of Engineering and Design, Technische Universität München, Garching, Germany
Biochemical Engineering, TUM School of Engineering and Design, Technische Universität München, Garching, Germany
Kremling, Andreas
Systems Biotechnology, TUM School of Engineering and Design, Technische Universität München, Garching, Germany
Enthalten in
Frontiers in Molecular Biosciences
Volume
9
Start Page
1
End Page
14
Article Number
806213
Citation
Frontiers in Molecular Biosciences 9: 1-14 (2022-03-08)
Publisher DOI
Scopus ID
Mathematical modeling is a promising tool for better understanding of cellular processes. In recent years, the development of coarse-grained models has gained attraction since these simple models are able to capture and describe a broad range of growth conditions. Coarse-grained models often comprise only two cellular components, a low molecular component as representative for central metabolism and energy generation and a macromolecular component, representing the entire proteome. A framework is presented that presents a strict mass conservative model for bacterial growth during a biotechnological production process. After providing interesting properties for the steady-state solution, applications are presented 1) for a production process of an amino acid and 2) production of a metabolite from central metabolism.
Schlagworte
kinetic model
mathematical modeling
metabolic and gene regulatory networks
metabolic engineering
microbial growth
resource allocation
systems biotechnology
DDC Class
624: Civil Engineering, Environmental Engineering
Publication version
publishedVersion
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Format
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