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Predictive modelling in mechanobiology : combining algorithms for cell activities in response to physical stimuli using a lattice-modelling approach
Publikationstyp
Journal Article
Date Issued
2012-12-10
Sprache
English
Author(s)
Journal
Volume
1
Issue
1
Start Page
423
End Page
435
Citation
Advanced Structured Materials 1 (1): 423-435 (2012)
Scopus ID
Publisher
Springer
ISBN
9783642052408
Computer simulation is a cornerstone of engineering design of high performance mechanical engineering equipment. However computer simulation is not so much used in the design of medical devices. The reasons for this are multifactorial and have their origin in the scepticism that biologists (and therefore clinicians) have regarding the plausibility of actually including all relevant factors in a computational model. In this work we have set out to model the response of tissues to changes in their mechanical environment, which could be caused by the presence of an implant or by damage of the tissue. We have used a lattice modelling approach, where the domain under analysis is discretized using both a finite element grid to compute biophysical stimuli and a 'lattice' to model cell activities. We applied the approach to two problems: (i) healing after bone fracture, and (ii) tissue regeneration inside a scaffold implanted into the body. © Springer-Verlag Berlin Heidelberg 2010.
DDC Class
610: Medicine, Health