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New insights in the morphological characterization and modelling of poly(ε-caprolactone) bone scaffolds obtained by supercritical CO₂ foaming
Citation Link: https://doi.org/10.15480/882.2957
Publikationstyp
Journal Article
Publikationsdatum
2020-08-07
Sprache
English
Institut
TORE-URI
Enthalten in
Volume
166
Article Number
105012
Citation
Journal of Supercritical Fluids (166): 105012 (2020-12-01)
Publisher DOI
Scopus ID
Publisher
Elsevier Science
Hierarchically porous synthetic bone grafts (scaffolds) are gaining attention in the clinical arena. Scaffolds should combine morphological (macro- and microporosity, pore interconnectivity), mechanical and biological (biocompatibility, degradation rate) properties to fit this specific use. Supercritical (sc-) foaming is a versatile scaffold processing technology. However, the selection of the optimum operating conditions to obtain a defined scaffold structure is hampered by the lack of a single characterization technique able to fully elucidate the porous features of the resulting scaffolds. In this work, the effect of soaking time (1, 3 and 5 h) on the preparation of poly(ε-caprolactone) (PCL, 50 kDa) scaffolds by sc-foaming was evaluated by a combined X-ray microtomography (μ-CT) and mercury intrusion porosimetry (MIP) 3D-morphological analysis. Mechanical tests and in silico modelling for cell penetration and water permeability of the scaffolds were also conducted. Results evidenced the relevance of μ-CT and MIP as a synergistic analytical duo to fully elucidate the morphology of the sc-foamed scaffolds and the soaking time effect.
Schlagworte
3D-biodegradable scaffolds
3D-modelling
Bone regeneration
Pore interconnectivity
Supercritical foaming
X-ray microtomography
DDC Class
600: Technik
More Funding Information
This research was funded by Xunta de Galicia [ED431F 2016/010],MCIUN [RTI2018-094131-A-I00], Agrupación Estratégica de Mate-riales [AeMAT-BIOMEDCO2, ED431E 2018/08], Agencia Estatalde Investigación [AEI] and FEDER funds.
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