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Microbial production of 2,3-butanediol
Publikationstyp
Book Part
Date Issued
2019-01-01
Sprache
English
Institut
TORE-URI
Start Page
147
End Page
151
Citation
Comprehensive Biotechnology: 147-151 (2019-01-01)
Publisher DOI
Scopus ID
Microbial production of 2,3-butanediol (2,3-BDL) was once conducted commercially in Europe until it could be made more cheaply from fossil oil sources. Interest in its biotechnological production resurfaced recently due to its diverse potential practical uses and the ever-decreasing availabilities of petroleum oil. Although not yet optimized, its production from renewable waste resources will make the process economically feasible and then offer an attractive alternative for traditional chemical synthesis. This chapter briefly reviews the basic properties and applications of 2,3-BDL. The variety of substrates, strains being used, including genetically improved strains, and their corresponding metabolic pathways are introduced. The current progress in bioprocess engineering, fermentation, and downstream processing is highlighted. Finally, challenges facing the economics of such process are discussed.
Subjects
2,3-Butanediol
Application
Fermentation
Metabolic engineering
Separation