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Synthesis of 2,6-dihydroxybenzoic acid by decarboxylase-catalyzed carboxylation using CO2 and in situ product removal
Citation Link: https://doi.org/10.15480/882.9058
Publikationstyp
Journal Article
Publikationsdatum
2024-01
Sprache
English
Enthalten in
Volume
12
Issue
1
Article Number
10
Citation
Processes 12 (1): 10 (2024-01)
Publisher DOI
Scopus ID
Publisher
MDPI
Peer Reviewed
true
For the enzymatic carboxylation of resorcinol to 2,6-dihydroxybenzoic acid (2,6-DHBA) using gaseous CO2 in an aqueous triethanolamine phase, an adsorption-based in situ product removal was demonstrated. The aim is to improve the reaction yield, which is limited by an unfavourable thermodynamic equilibrium. First, a screening for a high-affinity adsorber was carried out. Then, the application of a suitable adsorber was successfully demonstrated. This enabled achieving reaction yields above 80% using the adsorber for in situ product removal. The applied biotransformation was scaled up to 1.5 L at lab-scale. Furthermore, a downstream process based on the elution and purification of the product bound to the adsorber was developed to obtain 2,6-DHBA in high purity. Recycling is one of the key factors in this system, making it possible to recycle the reaction medium, the adsorber and the solvents in additional batches.
DDC Class
660: Chemistry; Chemical Engineering
Publication version
publishedVersion
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processes-12-00010-v2.pdf
Type
main article
Size
2.8 MB
Format
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