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Einfluss der Reaktorkonfiguration auf die Enantioselektivität einer kinetischen Racematspaltung
Other Titles
Influence of the reactor configuration on the enantioselectivity of a kinetic resolution
Publikationstyp
Journal Article
Date Issued
2013-05-23
Sprache
German
Author(s)
Institut
TORE-URI
Journal
Volume
85
Issue
6
Start Page
826
End Page
832
Citation
Chemie-Ingenieur-Technik 6 (85): 826-832 (2013)
Publisher DOI
Scopus ID
Publisher
Wiley-VCH Verl.
The optical purity of a product at the reactor outlet depends not only on the enantioselectivity of the catalyst, but also on the reactor configuration. Different reactor configurations are compared with respect to the enantiomeric excess (ee) at a respective conversion that can be achieved in a kinetic resolution of a racemate. For batch, fed-batch and plug flow reactors enantioselectivities (E value) of 35 are sufficient to achieve high enantiomeric excess. For a continuously operated stirred tank reactor high ee values are only obtained for E values higher than 190.
Subjects
Continuous stirred-tank reactor
Enantioselectivity
Kinetic resolution
Modeling
Reactor
DDC Class
570: Biowissenschaften, Biologie