Einfluss der Reaktorkonfiguration auf die Enantioselektivität einer kinetischen Racematspaltung [Influence of the reactor configuration on the enantioselectivity of a kinetic resolution]

Liese, Andreas; Kragl, Udo

Einfluss der Reaktorkonfiguration auf die Enantioselektivität einer kinetischen Racematspaltung [Influence of the reactor configuration on the enantioselectivity of a kinetic resolution]

Publikationstyp

Journal Article

Publikationsdatum

2013-05-23

Sprache

German

Author

Liese, Andreas

Kragl, Udo

Institut

Technische Biokatalyse V-6

TORE-URI

http://hdl.handle.net/11420/6774

Enthalten in

Chemie - Ingenieur - Technik

Volume

85

Issue

6

Start Page

826

End Page

832

Citation

Chemie-Ingenieur-Technik 6 (85): 826-832 (2013)

Publisher DOI

10.1002/cite.201300011

Scopus ID

2-s2.0-84878612714

Publisher

Wiley-VCH Verl.

The optical purity of a product at the reactor outlet depends not only on the enantioselectivity of the catalyst, but also on the reactor configuration. Different reactor configurations are compared with respect to the enantiomeric excess (ee) at a respective conversion that can be achieved in a kinetic resolution of a racemate. For batch, fed-batch and plug flow reactors enantioselectivities (E value) of 35 are sufficient to achieve high enantiomeric excess. For a continuously operated stirred tank reactor high ee values are only obtained for E values higher than 190. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Schlagworte

Continuous stirred-tank reactor

Enantioselectivity

Kinetic resolution

Modeling

Reactor

DDC Class

570: Biowissenschaften, Biologie

Options

Einfluss der Reaktorkonfiguration auf die Enantioselektivität einer kinetischen Racematspaltung [Influence of the reactor configuration on the enantioselectivity of a kinetic resolution]