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Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites
Publikationstyp
Journal Article
Date Issued
2024-06-06
Sprache
English
Author(s)
Zhang, Jieying
Xu, Yang
Zhou, Jing
Ma, Zhanfang
Mutti, Francesco G.
Zhu, Xingjun
Journal
Volume
36
Issue
23
Article Number
2402981
Citation
Advanced Materials 36 (23): 2402981 (2024)
Publisher DOI
Scopus ID
ISSN
09359648
The photothermal therapeutic effect on tumors located at different subcutaneous depths varies due to the attenuation of light by tissue. Here, based on the wavelength-dependent optical attenuation properties of tissues, the tumor depth is assessed using a multichannel lanthanide nanocomposite. A zeolitic imidazolate framework (ZIF-8)-coated nanocomposite is able to deliver high amounts of the hydrophilic heat shock protein 90 inhibitor epigallocatechin gallate through a hydrogen-bonding network formed by the encapsulated highly polarized polyoxometalate guest. It is superior to both bare and PEGylated ZIF-8 for drug delivery. With the assessment of tumor depth and accumulated amount of nanocomposite by fluorescence, an irradiation prescription can be customized to release sufficient HSP90 inhibitor and generate heat for sensitized photothermal treatment of tumors, which not only ensured therapeutic efficacy but also minimized damage to the surrounding tissues.
Subjects
drug delivery
fluorescent probes
heat shock protein
lanthanide-doped nanoparticles
photothermal therapy
DDC Class
600: Technology