Options
Combinatorial Synthesis of Peptoid Arrays via Laser-Based Stacking of Multiple Polymer Nanolayers
Publikationstyp
Journal Article
Date Issued
2019-03-01
Sprache
English
Author(s)
Streit, Bettina
Bhandari, Dhaka R.
Greifenstein, Juliane
Münch, Stephan W.
v. Bojničić-Kninski, Clemens
Spengler, Bernhard
Schepers, Ute
Bräse, Stefan
Volume
40
Issue
6
Article Number
1800533
Citation
Macromolecular Rapid Communications 40 (6): 1800533 (2019)
Publisher DOI
Scopus ID
ISSN
10221336
Here, the combinatorial synthesis of molecule arrays via a laser-assisted process is reported. Laser-transferred polymer nanolayers with embedded monomers, activators, or bases can be reliably stacked on top of each other, spot-by-spot, to synthesize molecule arrays. These various chemicals in the nanometer-thin layers are mixed by heat or solvent vapor, inducing coupling reactions. As an example, peptoid arrays with a density of 10 000 spots per cm <sup>2</sup> with the sub-monomer or monomer method are generated. Moreover, successful reactions spot-by-spot are verified by laser-transferring MALDI-matrix (Matrix-assisted laser desorption/ionization) followed by MALDI mass spectrometry imaging.
Subjects
high-throughput screening
laser-induced forward transfer
MALDI-MS imaging
molecule arrays
submonomer method
DDC Class
600: Technology