A novel anthropomorphic phantom composed of tissue-equivalent materials for use in experimental radiotherapy : design, dosimetry and biological pilot study

The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

Subjects

anthropomorphic phantom

CT scan

dosimetry

experimental radiotherapy

microbeam radiotherapy (MRT)

therapy planning

tissue-equivalent materials

DDC Class

570: Life Sciences, Biology

610: Medicine, Health

Publication version

publishedVersion

Lizenz

https://creativecommons.org/licenses/by/4.0/

Name

Breslin_2023_Arm_phantom_with_cover.pdf

Size

1.44 MB

Format

Adobe PDF

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A novel anthropomorphic phantom composed of tissue-equivalent materials for use in experimental radiotherapy : design, dosimetry and biological pilot study