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A novel anthropomorphic phantom composed of tissue-equivalent materials for use in experimental radiotherapy : design, dosimetry and biological pilot study
Citation Link: https://doi.org/10.15480/882.7977
Publikationstyp
Journal Article
Publikationsdatum
2023-05-31
Sprache
English
Author
Breslin, Thomas
Forrester, Helen
Rennau, Hannes
Cameron, Matthew
Häusermann, Daniel
Hall, Christopher
Enthalten in
Volume
8
Issue
2
Article Number
230
Citation
Biomimetics 8 (2): 230 (2023)
Publisher DOI
Scopus ID
Publisher
MDPI
Peer Reviewed
true
The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.
Schlagworte
anthropomorphic phantom
CT scan
dosimetry
experimental radiotherapy
microbeam radiotherapy (MRT)
therapy planning
tissue-equivalent materials
DDC Class
570: Life Sciences, Biology
610: Medicine, Health
Publication version
publishedVersion
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