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Adsorption of drugs on silica aerogels
Publikationstyp
Journal Article
Date Issued
2003-09-01
Sprache
English
Author(s)
Volume
19
Issue
20
Start Page
8521
End Page
8525
Citation
Langmuir 19 (20): 8521-8525 (2003-09-30)
Publisher DOI
Scopus ID
Publisher
ACS Publ.
The adsorption of drugs on silica aerogels has been investigated. Adsorption takes place from the solution of a corresponding drug in supercritical CO2. Adsorption isotherms were measured for one model substance, naphthalene, and two drugs, ketoprofen and miconazole, at 40°C. It has been shown that both drugs exhibit a high affinity to silica aerogel, what gives a possibility to use aerogels as a drug carrier in aerogel-drug formulations. The knowledge of the adsorption isotherm allows to control the loading of aerogels with drugs in such formulations. Both hydrophilic and hydrophobic aerogels can be used as a carrier. The influence of the hydrophobicity of the carrier material on the adsorption process is discussed.
DDC Class
540: Chemie