Experimental corrosion and computational hemodynamic assessment of a 3D-printed biodegradable stent design

Coronary artery disease (CAD) is a leading cardiovascular disorder caused by stenosis or occlusion of the coronary arteries. Stenting and bypass surgery are common treatment methods; however, conventional metal stents are prone to re-occlusion over time due to their permanent residence in the body. As a result, researchers have shown growing interest in biodegradable polymer stents. In this study, a novel stent and insert were 3D-printed with FDM and SLA using biocompatible PLA filament/resin. To assess corrosion resistance, the specimens were immersed in a simulated body fluid (SBF), and three corrosion tests were performed. Then, using field emission scanning electron (FESEM) images and 3D scanning, dimensional changes in the samples were extracted. The observations showed that in some places, the thickness of the samples increased by 0.1 mm compared to the original sample. Therefore, three samples with thickness increases of 0.1, 0.2, and 0.3 mm were designed and flow simulations were subsequently carried out. In simulations, the carreau viscosity model and pulsatile inlet flow were used. It was found that with increasing stent thickness, the insert becomes progressively less effective at increasing wall shear stress, leading to a higher probability of restenosis.

Content

Subjects

3D-print

Biodegradable

Corrosion

Hemodynamic

Insert

Stent

DDC Class

610: Medicine, Health

Files

Lizenz

https://creativecommons.org/licenses/by/4.0/

Publication version

publishedVersion

Download

Name

1-s2.0-S0264127526009305-main.pdf

Type

Main Article

Size

25.16 MB

Format

Adobe PDF