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  4. Pulmonary drug delivery with aerogels: engineering of alginate and alginate–hyaluronic acid microspheres
 
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Pulmonary drug delivery with aerogels: engineering of alginate and alginate–hyaluronic acid microspheres

Publikationstyp
Journal Article
Date Issued
2021
Sprache
English
Author(s)
Athamneh, Tamara  
Amin, Adil  
Benke, Edit  
Ambrus, Rita  
Gurikov, Pavel  
Smirnova, Irina  orcid-logo
Leopold, Claudia S.  
Institut
Entwicklung und Modellierung Neuartiger Nanoporöser Materialien V-EXK2  
Thermische Verfahrenstechnik V-8  
TORE-URI
http://hdl.handle.net/11420/10295
Journal
Pharmaceutical development and technology  
Volume
26
Issue
5
Start Page
509
End Page
521
Citation
Pharmaceutical Development and Technology 26 (5): 509-521 (2021)
Publisher DOI
10.1080/10837450.2021.1888979
Scopus ID
2-s2.0-85102917778
PubMed ID
33593203
In this study, the aerogel technology was used to prepare pulmonary drug carriers consisting of alginate and alginate–hyaluronic acid by an emulsion gelation technique and supercritical CO2 drying. During the preparation process, the emulsification rate and inner phase viscosity were varied to control the diameter of aerogel microspheres. Results showed that the aerogel microspheres were highly porous (porosity > 98%) with low densities in the range between 0.0087 and 0.0634 g/cm3 as well as high surface areas between 354 and 759 m2/g. The obtained microspheres showed aerodynamic diameter below 5 µm making them suitable for pulmonary drug delivery. An in vitro drug release study with the model drug sodium naproxen was conducted and a non-Fickian drug release mechanism was observed, with no significant difference between the release profiles of alginate and alginate–hyaluronic acid microspheres. During the emulsion gelation step, the feasibility of using the capillary number to estimate the largest stable droplet size in the emulsions was also studied and it was found that using this number, the droplet size in the emulsions may well be predicted.
Subjects
Aerogel
alginate
hyaluronic acid
microspheres
pulmonary drug delivery
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