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Enabling oxygen-dependent biocatalysis under fine bubble aeration in a rotating bed reactor
Citation Link: https://doi.org/10.15480/882.14932
Publikationstyp
Doctoral Thesis
Date Issued
2025
Sprache
English
Author(s)
Advisor
Referee
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2025-02-17
Institute
TORE-DOI
Citation
Technische Universität Hamburg (2025)
The scope of the thesis is the detailed investigation and demonstration of different approaches to overcome mass transfer limitations for the oxidative biocatalytic application in a modified reaction vessel of a rotating bed reactor. The benefits of the fine bubble aeration method over macrobubble aeration in application with a rotating packed bed reactor are demonstrated. Improved reaction rate and gas utilization are shown, resulting in increased catalytic productivity. Biocatalyst reuse, leading to efficient utilization of oxidases, was successfully applied. Considering the process limitations, the findings extend the potential use of fine bubble aeration for sustainable biotransformation processes using a rotating packed bed reactor.
Subjects
Microbubble aeration
Kinetic characterization / Modeling of biocatalytic reactions
Repetitive batch
Covalent immobilization
Sustainability
Biocatalytic oxidation
DDC Class
660.6: Biotechnology
540: Chemistry
Funding(s)
Fine Bubble Project
Funding Organisations
More Funding Information
German Research Foundation (DFG) - [501131738]
Publication version
acceptedVersion
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Name
2502_Dissertation_Percin.pdf
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4.23 MB
Format
Adobe PDF