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Enhancing the sensitivity of high-throughput plasmonic biosensors with microfluidics
Publikationstyp
Conference Paper
Date Issued
2016
Sprache
English
Author(s)
Start Page
1200
End Page
1201
Citation
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Microtas 2016
Contribution to Conference
Scopus ID
Publisher
Curran
ISBN of container
978-0-9798-0649-0
978-1-5108-3416-3
This paper presents how the ultimate sensitivity of a surface-based plasmonic Au nanohole array (Au-NHA) biosensor can be enhanced by a proper microfluidic design, improving analyte delivery for protein-protein interactions and leading to 10 times better limit of detection (LOD). We demonstrate the correspondence of experimental in-situ results with theoretical and numerical estimations for different microfluidic channel designs.
Subjects
Biosensors
Microfluidics
Multiplexing
Plasmonics
DDC Class
620: Engineering