TUHH Open Research
 

Fluid dynamic characterization of bioreactors on different scales by means of experimental and numerical lifeline analysis

Publikationstyp
Doctoral Thesis
Date Issued
2026
Sprache
English
Author(s)
Hofmann, Sebastian  orcid-logo
Advisor
Schlüter, Michael  orcid-logo
Referee
Hampel, Uwe  
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2026-01-16
Institute
Mehrphasenströmungen V-5  
TORE-DOI
10.15480/882.16854
TORE-URI
https://hdl.handle.net/11420/62121
First published in
Berichte aus dem Institut für Mehrphasenströmungen  
Number in series
17
Citation
Technische Universität Hamburg (2026)
This thesis investigates Lagrangian Sensor Particles (LSPs) to characterize hydrodynamics of bioreactors on industrial scale. Although LSPs enable lifeline measurements, their size limits flow-following accuracy. Experiments and Lattice-Boltzmann large eddy simulations complement each other, revealing micro-, macro-, and meso-scale flow structures, hydrodynamic compartments, and potential oxygen limitation zones. The results highlight the value of LSPs in providing essential data for scale-down model development and bioprocess optimization.
Subjects
Lagrangian Sensor Particles
4D-Particle Tracking Velocimetry
Trajectories
Lattice-Boltzmann Large Eddy Simulations
Flow-Following
Bioreactors
DDC Class
660.6: Biotechnology
530.42: Fluid Physics
Lizenz
https://creativecommons.org/licenses/by/4.0/
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