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Stereoselective synthesis of cyanohydrins: process development
Citation Link: https://doi.org/10.15480/882.1108
Other Titles
Stereoselektive Synthese von Cyanhydrinen: Prozessentwicklung
Publikationstyp
Doctoral Thesis
Date Issued
2013
Sprache
English
Author(s)
Advisor
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2012-08-31
Institut
TORE-DOI
A two step reaction sequence has been studied to synthesis stereoselectivly cyanohydrins starting with simple, commercially available building blocks. The first step was a Diels-Alder reaction catalysed by a Salen-metal catalyst covalently bound to a dendrimer. In the second step hydrogen cyanide was added stereoselectivly and enzymatically to the aldehyde formed in the first reaction. The reaction was catalysed by a hydroxynitrile lyase. The immobilisation of the enzyme as well as the application in non conventional reaction media were investigated. Both reaction kinetics were studied in batch reactions and in continuously operated membrane reactors. Mathematical models could be found describing the kinetics of the reactions. One focus of the study was the application of data driven calibration methods in combination with progress curve analysis to optimise kinetic models and multivariant calibration models simultaneously.
Subjects
Cyanhydrin
hydroxynitril lyase
Kinetik
Membranreaktor
Chemzym
cyanhydrine
hydroxynitril lyase
kinetic
membran reactor
chemzyme
DDC Class
660: Technische Chemie
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