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  4. Epoxy coenzyme a thioester pathways for degradation of aromatic compounds
 
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Epoxy coenzyme a thioester pathways for degradation of aromatic compounds

Publikationstyp
Journal Article
Date Issued
2012-07-18
Author(s)
Ismail, Wael  
Gescher, Johannes 
TORE-URI
http://hdl.handle.net/11420/14624
Journal
Applied and environmental microbiology  
Volume
78
Issue
15
Start Page
5043
End Page
5051
Citation
Applied and Environmental Microbiology 78 (15): 5043-5051 (2012-08-01)
Publisher DOI
10.1128/AEM.00633-12
Scopus ID
2-s2.0-84866182004
PubMed ID
22582071
Publisher
Soc.
Aromatic compounds (biogenic and anthropogenic) are abundant in the biosphere. Some of them are well-known environmental pollutants. Although the aromatic nucleus is relatively recalcitrant, microon of aromatic compounds. The adopted degradation pathways depend on the availabilorganisms have developed various catabolic routes that enable complete biodegradatiityof oxygen. Under oxic conditions, microorganisms utilize oxygen as a cosubstrate to activate and cleave the aromatic ring. In contrast, under anoxic conditions, the aromatic compounds are transformed to coenzyme A (CoA) thioesters followed by energyconsuming reduction of the ring. Eventually, the dearomatized ring is opened via a hydrolytic mechanism. Recently, novelcatabolic pathways for the aerobic degradation of aromatic compounds were elucidated that differ significantly from the established catabolic routes. The new pathways were investigated in detail for the aerobic bacterial degradation of benzoate and phenylacetate. In both cases, the pathway is initiated by transforming the substrate to a CoA thioester and all the intermediates are bound by CoA. The subsequent reactions involve epoxidation of the aromatic ring followed by hydrolytic ring cleavage. Here we discuss the novel pathways, with a particular focus on their unique features and occurrence as well as ecological significance.
DDC Class
570: Biowissenschaften, Biologie
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