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Multifunctional cellulose nanofibrils-GdF3 nanoparticles hybrid gel and its potential uses for drug delivery and magnetic resonance imaging
Publikationstyp
Journal Article
Date Issued
2023-11-06
Sprache
English
Author(s)
Jiang, Xuehe
Raveendran, Dhanya
Ovchinnikov, Kirill V.
Sochor, Benedikt
Mueller, Susanne
Boehm-Sturm, Philipp
Lerouge, Frédéric
Chaput, Frédéric
Navarro, Julien R.G.
Journal
Start Page
21182
End Page
21193
Citation
ACS Applied Nano Materials 6 (22): 21182–21193 (2023-11-06)
Publisher DOI
Scopus ID
Publisher
American Chemical Society
A multifunctional hybrid gel based on cellulose nanofibrils (CNFs) was developed by grafting on its surface stearyl acrylate (PSA) and gadolinium(III) fluoride nanoparticles (GdF3 NPs) via Cu0-mediated surface-initiated radical polymerization (SET-LRP) while encapsulating antimicrobial peptides in it. GdF3 NPs were first surface-modified with 11-phosphonoundecyl acrylate (PDA) to participate in the SET-LRP and cross-linked the grafted polymer-modified CNF. Several characterizations of the hybrid material (GdF3-PSA-CNF) were carried out, such as Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), rheology, and microscopic analyses. The grafted PSA and cross-linked GdF3 NPs created sophisticated networks in the CNF-based gel, presenting outstanding rheological properties and promising three-dimensional (3D) printability of this hybrid material (GdF3-PSA-CNF). The nanostructures of GdF3 NPs and their incorporated CNF species were characterized via small-angle X-ray scattering (SAXS). In addition, due to the unique intrinsic property of the GdF3 nanoparticles, properties for magnetic resonance imaging (MRI) of GdF3-PSA-CNF were investigated, showing the potential application as a contrast agent. Finally, the encapsulation of the antimicrobial peptides added another function to the hybrid material, evaluated by an antimicrobial test against methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
Subjects
3D gel-print
3D printing
bacteriocins
cellulose-based hybrid material
cellulose nanofibril (CNF)
contrast agent
gadolinium(III) fluoride nanoparticles
nanocellulose
single electron transfer living radical polymerization (SET-LRP)
DDC Class
620: Engineering