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Recovery of biologically produced 3-hydroxypropionaldehyde and its dehydrated product acrolein
Publikationstyp
Journal Article
Publikationsdatum
2014-05-17
Sprache
English
TORE-URI
Enthalten in
Volume
15
Issue
1
Start Page
133
End Page
139
Citation
Engineering in Life Sciences 1 (15): 133-139 (2015-01-01)
Publisher DOI
Scopus ID
Publisher
Wiley-VCH
3-Hydroxypropionaldehyde (3-HPA), which can be derived from biomass, is an important precursor for low-cost, large-volume acrolein-based chemicals like acrylic acid and acrylamide with a wide range of applications. In order to find an efficient process for isolating 3-HPA from fermentation broth, we comparatively investigated several separation methods including precipitation with hydrazides, immobilization with amines, reactive extraction with thiols, extraction with hydrophilic solvents, and reactive distillation as acrolein. It turned out that the reactive distillation is the most efficient method for in situ recovery of 3-HPA as acrolein. In a reactive distillation process at 37°C and Hammett acidity H0 = -1, the aldehyde concentration was reduced to 6 ± 1 mM in the transformation medium and increased to 1866 ± 146 mM in the distillate. The yield was 96 ± 8%. These experimental results are close to the calculated ideal equilibrium results assuming total dehydration of 3-HPA to acrolein. The main advantages of the reactive distillation process are that the recovery, purification, and concentration of acrolein are carried out in one step and the process is well suited for large-scale production at low costs.
Schlagworte
3-Hydroxypropionaldehyde
Acrolein
Distillation
In situ recovery
Reuterin
DDC Class
570: Biowissenschaften, Biologie
600: Technik
More Funding Information
This work was funded by the Hamburg University of Technology (TUHH).