Simulation of tissue differentiation in a mechanically loaded bone regeneration chamber

Publikationstyp
Conference Paper
Publikationsdatum
2008-12-01
Sprache
English
Author
Khayyeri, Hanifeh
Checa Esteban, Sara 
Tagil, M.
Prendergast, P. J.
TORE-URI
https://hdl.handle.net/11420/45700
First published in
IFMBE proceedings 
Number in series
22
Volume
22
Start Page
2031
End Page
2034
Citation
4th European Conference of the International Federation for Medical and Biological Engineering (ECIFMBE 2008)
Contribution to Conference
4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008 
Publisher DOI
10.1007/978-3-540-89208-3_484
Scopus ID
2-s2.0-70350662558
ISBN
9783540892076
Tissue differentiation can be regulated by mechanical loading. A bone chamber experiment has been conducted in order to investigate the effect of loading on tissue differentiation in vivo. In this study a computational model of the experiment was developed in which a mechano-regulation algorithm for stem cell differentiation in response to mechanical stimulus was combined with algorithms for cell migration, proliferation and apoptosis. The results show that the simulation is feasible to forecast the tissue differentiation process inside a bone chamber. © 2009 Springer Berlin Heidelberg.
Schlagworte
Bone chamber
Finite element model
Mechano-regulation
Numerical simulation
Tissue differentiation
DDC Class
570: Life Sciences, Biology
610: Medicine, Health