Options
Cellulose aerogel micro fibers for drug delivery applications
Citation Link: https://doi.org/10.15480/882.3717
Publikationstyp
Journal Article
Publikationsdatum
2021-05-20
Sprache
English
Volume
127
Article Number
112196
Citation
Materials Science and Engineering C 127: 112196 (2021-08-01)
Publisher DOI
Scopus ID
PubMed ID
34225849
Publisher
Elsevier
Textile engineering can offer a multi-scale toolbox via various fiber or textile fabrication methods to obtain woven or nonwoven aerogels with different structural and mechanical properties to overcome the current limitations of polysaccharide-based aerogels, such as poor mechanical properties and undeveloped shaping techniques. Hereby, a high viscous solution of microcrystalline cellulose and zinc chloride hydrate was wet spun to produce mono and multi-filament alcogel microfibers. Subsequently, cellulose aerogel fibers (CAF) were produced and impregnated with model drugs using supercritical CO2 processes. Fibers were characterized in terms of morphology and textural properties, thermal stability, mechanical properties, and in vitro biological and drug release assessments. Loaded and non-loaded CAFs proved to have a macro-porous outer shell and a nano-porous inner core with interconnected pore structure and a specific area in the range of 100–180 m2/g. The CAFs with larger diameter (d ~ 235 μm) were able to form knitted mesh while lower diameter fibers (d ~ 70 μm) formed needle punched nonwoven textiles. Humidity and water uptake assessments indicated that the fibrous structures were highly moisture absorbable and non-toxic with immediate drug release profiles due to the highly open interconnected porous structure of the fibers. Finally, CAFs are propitious to be further developed for biomedical applications such as drug delivery and wound care.
Schlagworte
Cellulose aerogel
Drug delivery
Microfibers
Supercritical CO 2
Wet spinning
DDC Class
600: Technik
More Funding Information
This project, as a part of the FibreNet consortium, has received funding from the European Union's Horizon 2020 - Research and Innovation
Framework Programme under the H2020 Marie Skłodowska-Curie Actions grant agreement No. 764713
Framework Programme under the H2020 Marie Skłodowska-Curie Actions grant agreement No. 764713
Publication version
publishedVersion
Loading...
Name
1-s2.0-S0928493121003362-main.pdf
Size
13.54 MB
Format
Adobe PDF