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Modular micro reaction engineering for carboligation catalyzed by benzoylformate decarboxylase
Citation Link: https://doi.org/10.15480/882.15514
Publikationstyp
Journal Article
Date Issued
2012-08-25
Sprache
English
TORE-DOI
Journal
Volume
1
Issue
4
Start Page
337
End Page
344
Citation
Green processing & synthesis 1 (4): 337–344 (2012)
Publisher DOI
Publisher
De Gruyter
Abstract The downscale of different unit operations for the biocatalytic carboligation of benzaldehyde and acetaldehyde catalyzed by benzoylformate decarboxylase from Pseudomonas putida was investigated. The reactor volume was reduced to 115 μl thus enabling a substrate and enzyme saving by a factor of 52 in comparison to standard laboratory techniques. Additionally, the successful downscale of membrane based liquid-liquid contactors was shown, which allows, for example, the screening of solvents for extraction as well as the feed of a substrate. Here, comparable volumes as well as residence times were realized, enabling the integration of all three unit operations.
Subjects
biocatalysis
downscale
enzyme
membrane
screening
DDC Class
660.2: Chemical Engineering
Publication version
publishedVersion
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Name
10.1515_gps-2012-0013.pdf
Type
Main Article
Size
1.16 MB
Format
Adobe PDF