Multi-Channel Lanthanide Nanocomposites for Customized Synergistic Treatment of Orthotopic Multi-Tumor Cases

Publikationstyp
Journal Article
Date Issued
2023-07-24
Sprache
English
Author(s)
Liu, Yuxin
Zhu, Xingjun
Wei, Zheng  
Wu, Kefan  
Zhang, Junfang  
Mutti, Francesco G.
Zhang, Hong  
Loeffler, Felix F.  
Zhou, Jing
TORE-URI
https://hdl.handle.net/11420/59384
Journal
Angewandte Chemie, International Edition  
Volume
62
Issue
30
Article Number
e202303570
Citation
Angewandte Chemie International Edition 62 (30): e202303570 (2023)
Publisher DOI
10.1002/anie.202303570
Scopus ID
2-s2.0-85158975655
ISSN
14337851
Simultaneous photothermal ablation of multiple tumors is limited by unpredictable photo-induced apoptosis, caused by individual intratumoral differences. Here, a multi-channel lanthanide nanocomposite was used to achieve tailored synergistic treatment of multiple subcutaneous orthotopic tumors under non-uniform whole-body infrared irradiation prescription. The nanocomposite reduces intratumoral glutathione by simultaneously activating the fluorescence and photothermal channels. The fluorescence provides individual information on different tumors, allowing customized prescriptions to be made. This enables optimal induction of hyperthermia and dosage of chemo drugs, to ensure treatment efficacy, while avoiding overtherapy. With an accessional therapeutic laser system, customized synergistic treatment of subcutaneous orthotopic cancer cases with multiple tumors is possible with both high efficacy and minimized side effects.
Subjects
Drug Release
Fluorescent Probes
Lanthanide-Doped Nanoparticles
Synergistic Therapy
Temperature Sensing
DDC Class
600: Technology