Relationship between physical, biochemical and biomechanical properties of tissue-engineered cartilage-carrier-constructs

Journal
Biotechnology letters  
Volume
27
Issue
3
Start Page
187
End Page
192
Citation
Biotechnology Letters 27 (3): 187-192 (2005)
Publisher DOI
10.1007/s10529-004-7859-4
Scopus ID
2-s2.0-17744375242
Publisher
Springer
Three-dimensional cartilage-carrier-constructs were produced according to a standard protocol from chondrocytes of an adult mini-pig. Physical parameters (height and weight) correlated very well with total DNA content (r 2=0.86, re. 0.94). The relation between DNA content and glycosaminoglycan content was less but still significant. No significant relationship was found between the elasticity module and the DNA content, even if the elasticity module increased slightly at higher DNA content. With respect to later implantation, selection of a construct for implantation based on the weight, which can be determined non-invasive and under sterile conditions, seems to be justifiable.
Subjects
Cartilage
Chondrocytes
Regression analysis
Tissue-engineering
DDC Class
610: Medicine, Health
620: Engineering