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Capillary network formation during tissue differentiation : a mechano-biological model
Publikationstyp
Conference Paper
Date Issued
2008-12-01
Sprache
English
Author(s)
Prendergast, Patrick J.
First published in
Number in series
22
Volume
22
Start Page
2195
End Page
2199
Citation
4th European Conference of the International Federation for Medical and Biological Engineering : ECIFMBE 2008 23–27 November 2008 Antwerp, Belgium / edited by R. Magjarevic, J. H. Nagel, Jos Vander Sloten, Pascal Verdonck, Marc Nyssen, Jens Haueisen. - Berlin, Heidelberg : Springer Berlin Heidelberg, 2009.- S. 2195-2199
Contribution to Conference
Publisher DOI
Scopus ID
Publisher
Springer
ISBN
9783540892076
Angiogenesis, the formation of new capillaries from pre-existing vessels, plays a critical role during bone regeneration and repair. In addition to an appropriate mechanical environment, sufficient supply of oxygen and nutrients is critical for bone formation. Mechano-biological models have been previously used to predict the time course of the differentiation process with the mechanical environment as the only regulator of cell activity. Here we propose a mechano-biological model for tissue differentiation where cell activity is regulated by both the local mechanical environment and the local vascularity. Results show a significant effect of the morphology of the new capillary network on bone formation and heterogeneous distributions of cells similar to those seen in histological studies.
Subjects
Angiogenesis
Blood vessel formation
Capillary network
Mechanobiology
Mechano-regulation
Tissue differentiation
DDC Class
610: Medicine, Health