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  4. Biocatalytic phosphorylations of metabolites: past, present, and future
 
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Biocatalytic phosphorylations of metabolites: past, present, and future

Publikationstyp
Review Article
Date Issued
2017-02-28
Sprache
English
Author(s)
Wohlgemuth, Roland  
Liese, Andreas  orcid-logo
Streit, Wolfgang R.  
Institut
Technische Biokatalyse V-6  
TORE-URI
http://hdl.handle.net/11420/3846
Journal
Trends in biotechnology  
Start Page
452
End Page
465
Citation
Trends in Biotechnology 5 (35): 452-465 (2017-05-01)
Publisher DOI
10.1016/j.tibtech.2017.01.005
Scopus ID
2-s2.0-85014111691
Publisher
Elsevier Science
Phosphorus is a key element for life that occurs in living cells as a structural part of many key biochemicals. Phosphorus plays important functional roles in biocatalysis, such as making metabolic reaction steps irreversible by transferring energy-rich groups, using phosphate groups as leaving groups, or selectively hydrolyzing phosphorus–oxygen or phosphorus–nitrogen bonds. The large number of biocatalysts known to catalyze the transfer of phosphorus-containing groups from donor molecules to acceptor molecules covers a wide variety of reaction classes. Bioprocessing technology can and should replicate these naturally occurring reactions. We illuminate some strategic advantages of this promising technology for developing biocatalytic processes and separation steps. Constraints, opportunities, and outlooks for implementing green engineering procedures to establish sustainable production processes are discussed.
DDC Class
540: Chemie
600: Technik
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